Strategies for the Development of Industrial Fungal Producing Strains

The use of microorganisms in industry has enabled the (over)production various compounds (e.g., primary and secondary metabolites, proteins enzymes) that are relevant for production antibiotics, food, beverages, cosmetics, chemicals biofuels, among others. Industrial strains commonly obtained by conventional (non-GMO) strain improvement strategies random screening selection. However, recombinant DNA technology made it possible to improve microbial adding, deleting or modifying specific genes. Techniques such as genetic engineering genome editing contributing development industrial strains. Nevertheless, there is still significant room further improvement. In this review, we will focus on classical recent methods, tools technologies used fungal with potential be applied at an scale. Additionally, functional genomics, transcriptomics, proteomics metabolomics together implementation manipulation techniques expression discussed.